Role of Triple Therapy in Asthma

Asthma is a chronic inflammatory airway disease characterised by variable airflow obstruction and recurrent symptoms such as wheeze, breathlessness, and cough. While many patients achieve control with standard inhaled therapies, a significant proportion remain symptomatic despite appropriate treatment, requiring escalation of care. Triple therapy—combining inhaled corticosteroids (ICS), long-acting beta-agonists (LABA), and long-acting muscarinic antagonists (LAMA)—has emerged as an important step-up treatment for patients with uncontrolled asthma. It targets multiple pathophysiological pathways, offering broader bronchodilation and anti-inflammatory effects.